ABSTRACT
The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95 percent confidence intervals (95 percentCI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6 percent). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95 percentCI = 0.15-1.81) and T/T (HR = 0.22; 95 percentCI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95 percentCI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95 percentCI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95 percentCI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95 percentCI = 0.26-1.78) and larynx cancer (HR = 0.93; 95 percentCI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Carcinoma, Squamous Cell/mortality , Head and Neck Neoplasms/mortality , /genetics , /genetics , Polymorphism, Genetic/genetics , Alcohol Drinking/adverse effects , Cohort Studies , Carcinoma, Squamous Cell/etiology , Disease-Free Survival , Educational Status , Genotype , Head and Neck Neoplasms/etiology , Prognosis , Risk Factors , Smoking/adverse effectsABSTRACT
Os autores apresentam a experiencia do Servico de Cabeca e Pescoco do Hospital Heliopolis em reconstrucao imediata de mandibula com enxerto autogeno de crista iliaca. Sao analisados, pormenorizadamente os 10 casos tratados entre Agosto/1979 e Junho/1982. Apresentam as idversas alternativas de reconstrucao imediatas e tardias da mandibula. Discutem as vantagens e desvantagens de cada metodo, e destacam os resultados dos transplantes osseos autogenos. Discutem os detalhes tecnicos indicacoes e resultados imediatos e tardios das reparacoes com crista iliaca. Concluem que os enxertos autogenos de crista iliaca oferecem bons resultados funcionais e esteticos, e que devem ser indicados nas recosntrucoes mandibulares apos resseccao de neoplasias benignas ou malignas de baixa gravidade